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  1. Fulltext. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women.

    Article - En anglais

    Fulltext.

    Background 

    Experimental studies in laboratory animals and humans suggest that alpha-linolenic acid (18 : 3n-3) may reduce the risk of arrhythmia.

    Objective 

    The objective was to examine the association between dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease (IHD).

    Design 

    This was a prospective cohort study.

    The intake of alpha-linolenic acid was derived from a 116-item food-frequency questionnaire completed in 1984 by 76283 women without previously diagnosed cancer or cardiovascular disease.

    Results 

    During 10 y of follow-up, we documented 232 cases of fatal IHD and 597 cases of nonfatal myocardial infarction.

    After adjustment for age, standard coronary risk factors, and dietary intake of linoleic acid and other nutrients, a higher intake of alpha-linolenic acid was associated with a lower relative risk (RR) of fatal IHD ; the RRs from the lowest to highest quintiles were 1.0,0.99,0.90,0.67, and 0.55 (95% CI : 0.32,0.94 ; P for trend=0.01).

    For nonfatal myocardial infarction there was only a modest, nonsignificant trend toward a reduced risk when extreme quintiles were compared (RR : 0.85 ; 95% CI : 0.61,1.19 ; P for trend=0.50).

    A higher intake of oil and vinegar salad dressing, an important source of alpha-linolenic acid, was associated with reduced risk of fatal IHD when women who consumed this food >=5-6 times/wk were compared with those who rarely consumed this food (RR : 0.46 ; 95% CI : 0.27,0.76 ; P for trend=0.001). (...)

    Mots-clés Pascal : Linolénique acide, Consommation alimentaire, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Stéréoisomère trans, Acide gras, Ischémie, Myocarde, Prévention, Lipide, Comportement alimentaire, Alimentation, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Cardiopathie coronaire, Myocarde pathologie, Homme, Femelle

    Mots-clés Pascal anglais : Linolenic acid, Food intake, Epidemiology, United States, North America, America, Trans stereoisomer, Fatty acids, Ischemia, Myocardium, Prevention, Lipids, Feeding behavior, Feeding, Cardiovascular disease, Vascular disease, Coronary heart disease, Myocardial disease, Human, Female

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0310689

    Code Inist : 002B12A03. Création : 16/11/1999.