Chemopreventive agents developed to be used in a moderate-risk but otherwise healthy population need to be both efficacious and to have minimal adverse effects.
The objective of this study was to evaluate the adverse effects of long-term retinol intake in a skin cancer chemoprevention trial in a large population at moderate risk for skin cancer.
Participants (n=2297) were randomly assigned to receive retinol [7576 retinol equivalents (RE), or 25 000 IU] or a placebo daily.
The adverse effects of retinol intake were studied by monitoring 14 clinical symptoms and laboratory indexes.
The median follow-up time was 3.8 y. Results : No adverse effects concerning the 14 symptoms were observed.
Significant differences in alkaline phosphatase (P<0.0001), triacylglycerol (P<0.0001), cholesterol (P=0.04), and HDL (P=0.01) were observed over time between the 2 groups.
After 49 mo of follow-up, alkaline phosphatase was 7% higher, triacylglycerol was 11% higher, cholesterol was 3% higher, and HDL was 1% lower in the retinol group than in the placebo group.
Because a 1% increase in cholesterol concentrations has been reported to be associated with a 2% increase in coronary artery disease risk, long-term ingestion of 7576 RE vitamin A/d should be considered with caution.
However, further studies are needed to confirm this finding.
Mots-clés Pascal : Essai longue durée, Rétinol, Régime alimentaire enrichi, Symptomatologie, Cellule sanguine, Analyse biochimique, Peau pathologie, Tumeur maligne, Prévention, Epidémiologie, Arizona, Etats Unis, Amérique du Nord, Amérique, Vitamine, Alimentation, Adulte, Homme
Mots-clés Pascal anglais : Long term test, Retinol, Supplemented diet, Symptomatology, Blood cell, Biochemical analysis, Skin disease, Malignant tumor, Prevention, Epidemiology, Arizona, United States, North America, America, Vitamin, Feeding, Adult, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0310086
Code Inist : 002B08A. Création : 16/11/1999.