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  1. Fulltext. Effects of long-term intake of retinol on selected clinical and laboratory indexes.

    Article - En anglais



    Chemopreventive agents developed to be used in a moderate-risk but otherwise healthy population need to be both efficacious and to have minimal adverse effects.


    The objective of this study was to evaluate the adverse effects of long-term retinol intake in a skin cancer chemoprevention trial in a large population at moderate risk for skin cancer.


    Participants (n=2297) were randomly assigned to receive retinol [7576 retinol equivalents (RE), or 25 000 IU] or a placebo daily.

    The adverse effects of retinol intake were studied by monitoring 14 clinical symptoms and laboratory indexes.

    The median follow-up time was 3.8 y. Results : No adverse effects concerning the 14 symptoms were observed.

    Significant differences in alkaline phosphatase (P<0.0001), triacylglycerol (P<0.0001), cholesterol (P=0.04), and HDL (P=0.01) were observed over time between the 2 groups.

    After 49 mo of follow-up, alkaline phosphatase was 7% higher, triacylglycerol was 11% higher, cholesterol was 3% higher, and HDL was 1% lower in the retinol group than in the placebo group.


    Because a 1% increase in cholesterol concentrations has been reported to be associated with a 2% increase in coronary artery disease risk, long-term ingestion of 7576 RE vitamin A/d should be considered with caution.

    However, further studies are needed to confirm this finding.

    Mots-clés Pascal : Essai longue durée, Rétinol, Régime alimentaire enrichi, Symptomatologie, Cellule sanguine, Analyse biochimique, Peau pathologie, Tumeur maligne, Prévention, Epidémiologie, Arizona, Etats Unis, Amérique du Nord, Amérique, Vitamine, Alimentation, Adulte, Homme

    Mots-clés Pascal anglais : Long term test, Retinol, Supplemented diet, Symptomatology, Blood cell, Biochemical analysis, Skin disease, Malignant tumor, Prevention, Epidemiology, Arizona, United States, North America, America, Vitamin, Feeding, Adult, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0310086

    Code Inist : 002B08A. Création : 16/11/1999.