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  1. The cost-effectiveness of methadone maintenance as a health care intervention.

    Article - En anglais


    Cost-effectiveness analysis using life-years of survival as the measure of treatment benefit is widely used in the economic evaluation of health care interventions but has not been applied to substance abuse treatment.

    The cost-effectiveness of methadone maintenance was evaluated to demonstrate the feasibility of applying this method to substance abuse treatment.


    A literature review was undertaken to determine the effect of methadone treatment on the rate of mortality associated with opiate addiction.

    Information was also obtained on the average cost and duration of treatment.

    A two-state Markov model was used to estimate the incremental effect of methadone on the life span and treatment cost of a a cohort of 25-year-old heroin users.


    Providing opiate addicts with access to methadone maintenance has an incremental cost-effectiveness ratio of $5915 per life-year gained (that is, for every year of life that is saved by providing methadone to opiate addicts, an additional $5915 in treatment costs are incurred).

    One-way sensitivity analysis determined that the ratio was less than $10 000 per-life year over a wide range of modeling assumptions.


    The ratio determined for methadone is lower than that of many common medical therapies, and well within the $50 000 threshold for judging cost-effectiveness. (...)

    Mots-clés Pascal : Toxicomanie, Service santé, Coût financement, Traitement substitutif, Chimiothérapie, Méthadone, Analgésique narcotique, Santé mentale, Etats Unis, Amérique du Nord, Amérique, Homme, Opiacés

    Mots-clés Pascal anglais : Drug addiction, Health service, Financing cost, Replacement therapy, Chemotherapy, Methadone, Narcotic analgesic, Mental health, United States, North America, America, Human, Opiates

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0309009

    Code Inist : 002B18H05B. Création : 16/11/1999.