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  1. The prevalence of depression in Alzheimer's disease and vascular dementia in a population sample.

    Article - En anglais


    Previous studies have shown that depression is more prevalent in vascular dementia than Alzheimer's s disease (AD).

    Subjects for these studies were either psychiatry or neurology patients, raising the issue of whether factors leading to treatment might have introduced sampling bias.


    Data for the present study came from the Canadian Study of Health and Aging (CSHA, 1994), a population-based prevalence study of dementia.

    AD was diagnosed using NINCDS-ADRDA criteria (McKhann et al., 1984), vascular dementia was diagnosed using draft ICD-10 criteria (World Health Organization, 1987) and the Ischemic Scale (Hachinski et al., 1975), major depression was diagnosed using an algorithm based on DSM-III-R criteria (American Psychiatric Association, 1987).

    The sample for the present study consisted of 481 subjects with AD and 140 with vascular dementia.


    The weighted prevalence rate of major depression was 3.2% for AD and 21.2% for vascular dementia, giving a crude odds ratio of 8.2 (95% Confidence Interval : 1.7-40.2).

    This finding was confirmed by a logistic regression analysis which adjusted for age, sex, place of residence (community, institution), self-reported health, severity of cognitive impairment, and antidepressant or beta-blocker use.


    Data on depressive symptoms were more often missing in subjects with dementia resulting in differential loss of potential study subjects. (...)

    Mots-clés Pascal : Démence Alzheimer, Démence vasculaire, Association morbide, Etat dépressif, Prévalence, Epidémiologie, Santé mentale, Canada, Amérique du Nord, Amérique, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Trouble humeur

    Mots-clés Pascal anglais : Alzheimer disease, Vascular dementia, Concomitant disease, Depression, Prevalence, Epidemiology, Mental health, Canada, North America, America, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Mood disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0308468

    Code Inist : 002B17G. Création : 16/11/1999.