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  1. Selective serotonin reuptake inhibitors have broadened the utilisation of antidepressant treatment in accordance with recommendations : Findings from a Swedish prescription database.

    Article - En anglais


    With the advent of the selective serotonin reuptake inhibitors (SSRls), the use of antidepressants has increased drastically in Sweden.

    The use of tricyclic antidepressants (TCAs) has, however, decreased.


    We surveyed a prescription database in the Swedish county of Jämtland and compared prescription patterns for patients prescribed SSRls with those prescribed TCAs.


    The incidence of treatments of antidepressants increased from 0.76% to 1.33% during the period 1991-1996.

    There were no significant differences between SSRls and TCAs with regard to patients having only one prescription dispensed within three months from the index prescription, or patients who switched class of antidepressant.

    Only a minority of the treatments were continued for at least six months, but significantly more SSRI than TCA treatments (42% and 27%). A second treatment period suggesting recurrence was three-times more common in the TCA group than in the SSRI group.


    Provided that the increased use of SSRls is mainly for depression, these drugs appear, despite a lower efficacy in severe depression, to have enabled a broader utilisation of antidepressants with regard to incidence, dosage and duration, in accordance with recommendations.

    Further analyses of this phenomenon relative to diagnostic criteria and outcome measures are required.

    Mots-clés Pascal : Etat dépressif, Traitement, Chimiothérapie, Antidépresseur, Psychotrope, Inhibiteur recapture, Sérotonine, Prescription médicale, Suède, Europe, Santé mentale, Homme, Trouble humeur

    Mots-clés Pascal anglais : Depression, Treatment, Chemotherapy, Antidepressant agent, Psychotropic, Reuptake inhibitor, Serotonin, Medical prescription, Sweden, Europe, Mental health, Human, Mood disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0308447

    Code Inist : 002B18H05B. Création : 16/11/1999.