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  1. Methadone-maintained former heroin addicts, including those who are anti-HIV-1 seropositive, comply with and respond to hepatitis B vaccination.

    Article - En anglais


    To study the efficacy of standard hepatitis B (HB) vaccination in methadone-maintained former intravenous drug users.


    HB vaccine was administercd to subjects at 0,1 and 6 months.


    Two university-affiliated methadone maintenance clinics.


    Forty-three HB-unexposed former heroin addicts in methadone maintenance treatment for heroin addiction.


    HB surface antibody (anti-HBs) response to the vaccine was assessed at 0,1,6 and >= 12 months ; anti-HIV-1 status was also assessed.


    Thirty-seven patients (86%) completed the 6-month vaccination series.

    Of the 30 anti-HIV-1 scronegative patients who then completed the entire 12-month protocol, 21 (70%) seroconverted (anti-HBs ratio>2.1) and 19 (63%) were protected (anti-HBs ratio>10).

    Two other subjects were anti-HIV-1 seropositive 

    One was HB-protected at 12 months but later lost immunity.

    Ten anti-hepatitis C antibody-positive patients completed the 12-month study and six were protected ; thus, there was no significant relationship between hepatitis C status and HB vaccine respouse.


    Standard HB vaccination is both feasible and effective.

    Mots-clés Pascal : Toxicomanie, Héroïne, Prévention, Hépatite virale B, Virose, Infection, Vaccination, Homme, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Drug addiction, Heroin, Prevention, Viral hepatitis B, Viral disease, Infection, Vaccination, Human, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0308334

    Code Inist : 002B30A03B. Création : 16/11/1999.