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  1. Resolution and resurgence of Schistosoma haematobium-induced pathology after community-based chemotherapy in Ghana, as detected by ultrasound.

    Article - En anglais

    Community-based treatment is recommended for endemic populations with urinary schistosomiasis ; however, the optimal target group for treatment and retreatment interval have not been established.

    Using ultrasound, this study identified subpopulations whose lesions were most likely to respond to treatment and characterized resurgence of pathology.

    Ultrasound examination of 1202 infected patients was followed by chemotherapy with praziquantel.

    A sample of 698 patients was followed for 18 months after treatment.

    Nearly all types of bladder pathologies resolved after treatment, regardless of patient's age or intensity of initial infection.

    However, many patients'upper urinary tract pathologies (62.5%) did not resolve.

    During the 18-month follow-up period, reappearance of severe bladder pathologies was rare, and<10% of persons had resurgence of mild bladder pathologies.

    For this population, retreatment is not needed annually but might be cost effective if given several years later.

    Confirmation from other areas is required before general policies can be formed.

    Mots-clés Pascal : Schistosoma haematobium, Trematoda, Plathelmintha, Helmintha, Invertebrata, Homme, Epidémiologie, Prévalence, Réinfection, Traitement, Chimiothérapie, Antiparasitaire, Imagerie ultrasonore, Etude longitudinale, Facteur risque, Age, Schistosomiase, Trématodose, Helminthiase, Parasitose, Infection, Appareil urinaire pathologie, Ghana, Afrique

    Mots-clés Pascal anglais : Schistosoma haematobium, Trematoda, Plathelmintha, Helmintha, Invertebrata, Human, Epidemiology, Prevalence, Reinfection, Treatment, Chemotherapy, Parasiticid, Ultrasound imaging, Follow up study, Risk factor, Age, Schistosomiasis, Trematode disease, Helminthiasis, Parasitosis, Infection, Urinary system disease, Ghana, Africa

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0307978

    Code Inist : 002B05E03C1. Création : 16/11/1999.