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  1. Clinical and laboratory manifestations of systemic sclerosis (scleroderma) in Black South Africans.

    Article - En anglais

    A retrospective study of systemic sclerosis (SSc) in Blacks attending a tertiary hospital on the Witwatersrand, South Africa, was undertaken.

    The female : male ratio of the 63 patients was 4.6 : 1 and the mean age of onset of SSc was 36.1 yr.

    Four of the 1 males were ex-goldminers and nine females resided close to goldmines.

    Forty-one patients had diffuse cutaneous SSc (dcSSc), 18 had limited cutaneous SSc (lcSSc) and four were unclassified.

    Overall, 56% had pulmonary fibrosis, 37% had myositis and 98% were antinuclear antibody (ANA) positive, with a notable absence of anti-centromere antibodies.

    Subset comparisons showed myositis and a reduced forced vital capacity to be significantly more common with dcSSc than lcSSc.

    The only significant sex differences were that arthralgia/arthritis was more common in women, while calcinosis occurred more frequently in men.

    Seven of the eight known deaths occurred in patients with dcSSc.

    These findings, particularly the age of disease onset, predominance of the dcSSc subset, inflammatory features of myositis and a raised erythrocyte sedimentation rate, and absence of anti-centromere antibodies, are similar to those reported previously in African-Americans.

    Mots-clés Pascal : Sclérodermie, Symptomatologie, Analyse biochimique, Epidémiologie, Prévalence, Ethnie, Négroïde, République Sud Africaine, Afrique, Homme, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie

    Mots-clés Pascal anglais : Scleroderma, Symptomatology, Biochemical analysis, Epidemiology, Prevalence, Ethnic group, Negroid, South Africa(Republic), Africa, Human, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0307149

    Code Inist : 002B07. Création : 16/11/1999.