The incidence of esophageal and gastric cardia adenocarcinoma is, for unknown reasons, increasing dramatically.
A weak and inconsistent association between body mass index (BMI) and adenocarcinoma of the esophagus and gastric cardia has been reported.
To reexamine the association between BMI and development of adenocarcinoma of the esophagus and gastric cardia.
Nationwide, population-based case-control study.
Sweden, 1995 through 1997.
Patients younger than 80 years of age who had recently received a diagnosis were eligible.
Comprehensive organization ensured rapid case ascertainment.
Controls were randomly selected from the continuously updated population register.
Interviews were conducted with 189 patients with adenocarcinoma of the esophagus and 262 patients with adenocarcinoma of the gastric cardia ; for comparison, 167 patients with incident esophageal squamous-cell carcinoma and 820 controls were also interviewed.
Odds ratios were determined from BMI and cancer case-control status.
Odds ratios estimated the relative risk for the two adenocarcinomas studied and were calculated by multivariate logistic regression with adjustment for potential confounding factors.
A strong dose-dependent relation existed between BMI and esophageal adenocarcinoma.
The adjusted odds ratio was 7.6 (95% Cl, 3.8 to 15.2) among persons in the highest BMI quartile compared with persons in the lowest. (...)
Mots-clés Pascal : Adénocarcinome, Oesophage, Cardia, Indice masse corporelle, Obésité, Epidémiologie, Facteur risque, Homme, Suède, Europe, Tumeur maligne, Appareil digestif pathologie, Estomac pathologie, Oesophage pathologie
Mots-clés Pascal anglais : Adenocarcinoma, Esophagus, Cardia, Body mass index, Obesity, Epidemiology, Risk factor, Human, Sweden, Europe, Malignant tumor, Digestive diseases, Gastric disease, Esophageal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0302000
Code Inist : 002B13B01. Création : 16/11/1999.