Flavonoids, a group of phenolic compounds found in fruits and vegetables, are known to have antioxidant properties.
They prevent low density lipoprotein oxidation in vitro and thus may play a role in the prevention of coronary heart disease (CHD).
In 1986, in a prospective study of 34,492 postmenopausal women in lowa, the authors examined the association of flavonoid intake with CHD and stroke mortality.
Over 10 years of follow-up, 438 deaths from CHD and 131 deaths from stroke were documented.
Total flavonoid intake was associated with a decreased risk of CHD death after adjusting for age and energy intake (p for trend=0.04).
This association was attenuated after multivariate adjustment.
However, decreased risk was seen in each category of intake compared with the lowest.
Relative risks and 95% confidence intervals of CHD death from lowest to highest intake category were 1.0,0.67 (95% confidence interval (Cl) 0.49-0.92), 0.56 (95% Cl 0.39-0.79), 0.86 (95% Cl 0.63-1.18), and 0.62 (95% Cl 0.44-0.87).
There was no association between total flavonoid intake and stroke mortality (p for trend=0.83).
Of the foods that contributed the most to flavonoid intake in this cohort, only broccoli was strongly associated with reduced risk of CHD death.
The data of this study suggest that flavonoid intake may reduce risk of death from CHD in postmenopausal women.
Mots-clés Pascal : Cardiopathie coronaire, Postménopause, Accident cérébrovasculaire, Mortalité, Régime alimentaire, Flavonoïde, Antioxydant, Epidémiologie, Facteur risque, Homme, Femelle, Etude cohorte, Iowa, Etats Unis, Amérique du Nord, Amérique, Appareil circulatoire pathologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Coronary heart disease, Postmenopause, Stroke, Mortality, Diet, Flavonoid, Antioxidant, Epidemiology, Risk factor, Human, Female, Cohort study, Iowa, United States, North America, America, Cardiovascular disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0301776
Code Inist : 002B17C. Création : 16/11/1999.