Clinical course and risk factors of hepatitis C virus related liver disease in the general population : report from the Dionysos study.
Background-The severity, clinical course, and risk of hepatitis C virus (HCV) related chronic liver disease are still rather poorly defined.
Aims-To investigate the prevalence, risk factors, and severity of HCV related liver disease in the general population, and investigate whether infection with a specific genotype is associated with an increased risk of cirrhosis or hepatocellular carcinoma.
Methods-HCV RNA determination by polymerase chain reaction (PCR) and HCV genotyping were performed in all anti-HCV positive subjects belonging to the Dionysos study (6917 subjects).
Diagnosis of cirrhosis and hepatocellular carcinoma was established by liver biopsy in all cases.
All the data were analysed by univariate and multivariate statistics in all the cohort.
To investigate the natural history of HCV infection, anti-HCV positive subjects were followed up every six months for three years with liver function tests and ultrasonograms.
The overall prevalence of HCV RNA positivity was 2.3%. Positivity increased progressively with age, and was higher in women (ratio of men to women=0.7).
Genotypes 1b and 2a were the most frequent (42 and 24% of HCV RNA positive patients), with a prevalence of 1 and 0.6% respectively.
Intravenous drug use, blood transfusions received before 1990, history of previous hepatitis among the cohabiting, and history of animal (mainly dogs) bites were significantly (p<0.05) associated with HCV infection, independently of age and sex. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Prévalence, Facteur risque, Cirrhose, Insuffisance hépatique, Etude cohorte, Gravité, Séropositivité, Génotype, Carcinome hépatocellulaire, Homme, Italie, Europe, Evaluation, Appareil digestif pathologie, Foie pathologie, Organisation santé, Tumeur maligne, Etude Dionysos
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Prevalence, Risk factor, Cirrhosis, Liver failure, Cohort study, Gravity, Seropositivity, Genotype, Hepatocellular carcinoma, Human, Italy, Europe, Evaluation, Digestive diseases, Hepatic disease, Public health organization, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0301100
Code Inist : 002B05C02G. Création : 16/11/1999.