To investigate the clinical and sociomedical outcome in patients with various clinical manifestations of humidifier disease and work related asthma after removal from further exposure.
Methods-Follow up investigation (range 1-13 years) of respiratory symptoms, spirometry, airway responsiveness, sickness absence, and working situation in patients with (I) humidifier fever (n=12), (II) obstructive type of humidifier lung (n=8), (III) restrictive type of humidifier lung (n=4), and (IV) work related asthma (n=22).
All patients were working at departments in synthetic fibre plants with microbiological exposure from contaminated humidification systems or exposure to small particles (<1 mum) of oil mist.
At follow up patients with work related asthma were less often symptom free (37%, 7119) than patients with humidifier disease (I, II, III) (67%, 16124).
Mean forced expiratory volume in one second (FEV,) of patients with obstructive impairment had been increased significantly at follow up but still remained below the predicted value.
Mean forced vital capacity (FVC) of patients with initially restrictive impairment had returned to normal values at follow up.
Airway hyperresponsiveness at diagnosis persisted in patients with obstructive impairment (II+IV 14/17, but disappeared in patients with humidifier fever (3/3) and restrictive type of humidifier lung (212). (...)
Mots-clés Pascal : Maladie professionnelle, Médecine travail, Fibre synthétique, Asthme, Industrie, Poumon humidificateur, Etude longitudinale, Milieu professionnel, Comparaison intraindividuelle, Changement, Homme, Statut professionnel, Pollution air, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Poumon pathologie, Pneumopathie interstitielle, Immunopathologie, Allergie, Devenir malade
Mots-clés Pascal anglais : Occupational disease, Occupational medicine, Synthetic fiber, Asthma, Industry, Humidifiers pneumonitis, Follow up study, Occupational environment, Intraindividual comparison, Change, Human, Professional status, Air pollution, Respiratory disease, Obstructive pulmonary disease, Lung disease, Interstitial pneumonitis, Immunopathology, Allergy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0300973
Code Inist : 002B06C02. Création : 16/11/1999.