Although numerous studies have demonstrated obesity as an aspect of the insulin resistance syndrome in cardiovascular disease (CVD), the mechanism is not clear.
Central adiposity, acting through many CVD risk factors, including, plasma glucose, insulin, total cholesterol, low density lipoprotein-cholesterol (LDL-C) and lipoprotein moities-apolipoprotein B (ApoB), apolipoprotein A-I (ApoAl), by atherogenic and thrombotic mechanisms has been proposed as a possible mechanism.
In this study, we examined the relationship between central fat distribution (defined by waist circumference) and the ratio of these lipoproteins (ApoB/ApoAl).
Association between ApoB/ApoAl ratio and waist circumference was compared in Blacks (n=854) and Whites (n=2552) using the NHANES III population-based samples.
Correlation analyses and multiple regression analyses were used to determine the association between ApoB/ApoAl and waist circumference, controlling for age, body mass index (BMI), race, gender, plasma glucose, insulin, serum triglyceride and total cholesterol.
Adjusting for age, ApoB/ApoAl was significantly correlated with waist circumference (Black men : r=0.38, White men : r=0.26, Black women : r=0.20, White women : r=0.36) (all P<0.01). (...)
Mots-clés Pascal : Obésité, Masse grasse, Distribution, Anthropométrie, Etude comparative, Apolipoprotéine B, Apolipoprotéine AI, Plasma sanguin, Insuline, Résistance tissu cible, Lipémie, Origine ethnique, Epidémiologie, Caucasoïde, Adulte, Homme, Personne âgée, Négroïde, Etats Unis, Amérique du Nord, Amérique, Etat nutritionnel, Trouble nutrition, Hormone pancréatique, Endocrinopathie
Mots-clés Pascal anglais : Obesity, Fat mass, Distribution, Anthropometry, Comparative study, Apolipoprotein B, Apolipoprotein AI, Blood plasma, Insulin, Target tissue resistance, Lipemia, Ethnic origin, Epidemiology, Caucasoid, Adult, Human, Elderly, Negroid, United States, North America, America, Nutritional status, Nutrition disorder, Pancreatic hormone, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0300794
Code Inist : 002B30A01A2. Création : 16/11/1999.