To evaluate the possible effects of paraquat spraying among workers on deciduous fruit farms in the Western Cape, South Africa.
Paraquat is a commonly used herbicide world wide and is a well documented cause of pulmonary fibrosis in studies of laboratory animals and in humans after exposure to a high dose (usually accidental or as parasuicide).
The respiratory effects of long term, low dose exposure to paraquat have not been fully evaluated.
Administered questionnaires generated information on exposure, respiratory symptoms, and potential confounding variables.
Spirometry and gas transfer were measured and chest radiographs performed.
Oxygen desaturation on exercise testing was by oximetry during a modified stage one exercise test.
No association was found between long term exposure to paraquat and reported symptoms, spirometry (forced vital capacity (FVC), forced expiratory volume in 1 second (FEV,), FEV1/FVC) and gas transfer (TLCO and KCO) or chest radiography.
Multivariate analysis showed a significant relation between measures of long term exposure to paraquat and arterial oxygen desaturation during exercise independent of short term exposure.
Conclusion-Previous studies have not shown a significant relation between measures of exposure to paraquat and standard tests of lung function.
Arterial oxygen desaturation during exercise represents a more sensitive test. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Agriculture, Toxicité, Surveillance, Poumon pathologie, Homme, Fonction respiratoire, Evaluation, Long terme, Dose faible, Exercice physique, Oxymétrie, Méthodologie, Ammonium quaternaire composé, Appareil respiratoire pathologie, Paraquat
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Agriculture, Toxicity, Surveillance, Lung disease, Human, Lung function, Evaluation, Long term, Low dose, Physical exercise, Oxymetry, Methodology, Quaternary ammonium compound, Respiratory disease, Paraquat
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0300605
Code Inist : 002B03G. Création : 16/11/1999.