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  1. Genetic and environmental influences on total-body and central abdominal fat : The effect of physical activity in female twins.

    Article - En anglais


    The increasing prevalence of obesity has focused attention on the contribution of physical activity and its interaction with predisposing genetic factors.


    To examine 1) the relation between physical activity and total-body and central abdominal fat, independent of genetic and other environmental factors, and 2) the influence of physical activity in persons who are genetically susceptible to generalized or central adiposity.


    Cross-sectional study.


    A London academic teaching hospital.


    970 healthy female twins (mean age, 55.5 years [range, 39 to 70 years] ; body mass index, 24.4 kg/m2 [range, 16.4 to 44.0 kg/mg2]). There were 241 monozygotic pairs, 228 dizygotic pairs, and 32 women whose co-twin lacked complete data.

    Fifty-six percent of participants were of normal weight, 30% were overweight, 7% were obese, and 7% were underweight.


    Total-body and central abdominal fat were measured by dual-energy x-ray absorptiometry.

    Physical activity was assessed by quantitative and semiquantitative questionnaires.

    Data on dietary intake, socioeconomic status, smoking status, and use of hormone replacement therapy (HRT) were also gathered.


    Total-body and abdominal central adiposity were lower with higher levels of home, sporting, and sweating-associated activity.

    Total-body and central abdominal fat were 5.6 kg and 0.44 kg lower, respectively, in participants who reported vigorous weight-bearing activity. (...)

    Mots-clés Pascal : Obésité, Génétique, Exercice physique, Epidémiologie, Prévalence, Facteur risque, Homme, Femelle, Jumeau, Angleterre, Grande Bretagne, Royaume Uni, Europe

    Mots-clés Pascal anglais : Obesity, Genetics, Physical exercise, Epidemiology, Prevalence, Risk factor, Human, Female, Twin, England, Great Britain, United Kingdom, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0300448

    Code Inist : 002B22B. Création : 16/11/1999.