An infectious etiology of testicular cancer has been suggested.
We have evaluated seroreactivity against cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in relation to testicular-cancer risk in a case-control study, nested within a cohort of prospectively collected serum specimens from 293,692 individuals.
For each of 81 cases of testicular cancer identified, 3 controls were randomly selected from the cohort.
Serum IgG antibody titers against CMV and EBV were determined using enzyme-linked immunosorbent assays (ELISAs) and immunofluorescence methods.
Odds ratios (OR) were obtained from conditional logistic-regression models.
No association was found between CMV positivity and testicular cancer overall (OR=1.08 ; 95% confidence interval 0.60-1.94) ; risk for testicular seminoma was increased among CMV seropositive [OR=1.70 (0.80-3.59) ], whereas seropositivity was associated with decreased risk for testicular non-seminoma [OR=0.54 (0.19-1.56) ] (p for heterogeneity, 0.09).
For EBV, the risk for testicular cancer was increased among individuals seropositive for viral capsid antigen (VCA) [OR=2.74 (0.62-12.12) ]. The results lend some support to the hypothesis of an infectious etiology, and we propose that future studies should take into account age at infection.
Mots-clés Pascal : Tumeur maligne, Testicule, Facteur risque, Epidémiologie, Virose, Infection, Virus Epstein Barr, Gammaherpesvirinae, Herpesviridae, Virus, Cytomegalovirus humain, Betaherpesvirinae, Etiologie, Etude cas témoin, Norvège, Europe, Homme, Appareil génital mâle pathologie, Testicule pathologie
Mots-clés Pascal anglais : Malignant tumor, Testicle, Risk factor, Epidemiology, Viral disease, Infection, Epstein Barr virus, Gammaherpesvirinae, Herpesviridae, Virus, Human cytomegalovirus, Betaherpesvirinae, Etiology, Case control study, Norway, Europe, Human, Male genital diseases, Testicular diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0299294
Code Inist : 002B20B02. Création : 16/11/1999.