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  1. Does a family history of cancer increase the risk for postmenopausal endometrial carcinoma ? A prospective cohort study and a nested case-control family study of older women.

    Article, Communication - En anglais

    Annual Association of Cancer Research annual meeting. New Orleans, LA, USA, 1998/04.


    As part of the hereditary nonpolyposis colon carcinoma (HNPCC) constellation of neoplasia caused by defects in mismatch repair genes, some endometrial carcinomas are known to have a genetic contribution to etiology.

    However, most endometrial carcinomas occur in postmenopausal women, presumably without the HNPCC defect.

    Consequently, the genetic contribution to these cases is unclear.

    The objective of this study was to determine whether family history of cancer is a risk factor for endometrial carcinoma in older women.


    The authors analyzed incident endometrial carcinoma data, as well as data on family history of various cancers in first-degree relatives, from a cohort of 24,848 postmenopausal Iowa women ages 55-69 years who were cancer free at baseline in 1986.

    Because a positive family history is dependent on many factors, including the age of the patient, the number of relatives, and the distribution of other risk factors in relatives, the authors also conducted a nested case-control study on family members of 95 patients with endometrial carcinoma diagnosed during 1988-1989 and 91 cancer free controls who were chosen randomly from subjects matched for age (±1 year).


    During 10 years of follow-up of the cohort, 322 incident endometrial carcinoma cases occurred.

    Women who reported a positive family history of cancer overall or at any specific site (e.g. (...)

    Mots-clés Pascal : Carcinome, Endomètre, Facteur risque, Epidémiologie, Tumeur maligne, Histoire familiale, Antécédent, Postménopause, Etude cas témoin, Etude cohorte, Etats Unis, Amérique du Nord, Amérique, Adulte, Homme, Personne âgée, Appareil génital femelle pathologie, Utérus pathologie

    Mots-clés Pascal anglais : Carcinoma, Endometrium, Risk factor, Epidemiology, Malignant tumor, Family story, Antecedent, Postmenopause, Case control study, Cohort study, United States, North America, America, Adult, Human, Elderly, Female genital diseases, Uterine diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0294533

    Code Inist : 002B20C02. Création : 16/11/1999.