Breast carcinoma risk may be modified by early life factors, including physical growth and development, diet, and life-style factors of preadolescence and adolescence, as well as genetic factors.
The authors tested their hypothesis that adolescent growth and development are related to breast carcinoma incidence by evaluating 65,140 women who participated in the Nurses'Health Study.
During 16 years of follow-up, 806 women were diagnosed with breast carcinoma prior to menopause, and another 1485 were diagnosed after menopause.
Because adolescent growth was not directly observed in this cohort, the peak height growth velocity for each participant was estimated by using a model from another longitudinal study.
Finally, Cox proportional hazards regression models were used to study associations between breast carcinoma incidence and adolescent factors in the Nurses'Health Study.
Later menarche (relative risk [RR]=0.52 for >=15 vs. <=11 years) and more body fatness at age 10 years (RR=0.60 for fattest vs. leanest) were associated with a decreased risk of premenopausal breast carcinoma.
The risk of postmenopausal breast carcinoma was lower for girls with later menarche (RR=0.80), more body fat at age 10 years (RR=0.72), and shorter adult height (RR=1.29 for >=67 vs.<62 inches).
Higher peak height growth velocity, derived from these 3 variables, was associated with increased risk of both premenopausal (...)
Mots-clés Pascal : Carcinome, Glande mammaire, Facteur risque, Première menstruation, Tardif, Tissu adipeux, Développement staturopondéral, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Tumeur maligne, Glande mammaire pathologie, Adolescence
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Risk factor, Menarche, Late, Adipose tissue, Somatic growth, Epidemiology, United States, North America, America, Human, Malignant tumor, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0294374
Code Inist : 002B20E02. Création : 16/11/1999.