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  1. Urinary I-hydroxypyrene as a biomarker of exposure to polycyclic aromatic hydrocarbons : biological monitoring strategies and methodology for determining biological exposure indices for various work environments.

    Article - En anglais

    This article reviews the published studies on urinary 1-hydroxypyrene (1-OHP) as a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs) in work environments.

    Sampling and analysis strategies as well as a methodology for determining biological exposure indices (BEIs) of 1-OHP in urine for different work environments are proposed for the biological monitoring of occupational exposure to PAHs.

    Owing to the kinetics of absorption of pyrene by different exposure routes and excretion of 1-OHP in urine, in general, 1-OHP urinary excretion levels increase during the course of a work day, reaching maximum values 3-9 h after the end of work.

    When the contribution of dermal exposure is important, post-shift 1-OHP excretion can however be lower than pre-shift levels in the case where a worker has been exposed occupationally to PAHs on the day prior to sampling.

    In addition, 1-OHP excretion levels in either pre-shift, post-shift or evening samples increase during the course of a work-week, levelling off after three consecutive days of work.

    Consequently, ideally, for a first characterization of a work environment and for an indication of the major exposure route, considering a 5-day work-week (Monday to Friday), the best sampling strategy would be to collect all micturitions over 24 h starting on Monday morning.

    Alternatively, collection of pre-shift, post-shift and evening urine samples on the first day of the work-week and at the end of the work-week is recommended. (...)

    Mots-clés Pascal : Composé aromatique polycyclique, Exposition professionnelle, Médecine travail, Surveillance biologique, Homme, Marqueur biologique, Urine, Liquide biologique, Pyrène(1-hydroxy)

    Mots-clés Pascal anglais : Polycyclic aromatic compound, Occupational exposure, Occupational medicine, Biological monitoring, Human, Biological marker, Urine, Biological fluid

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0293608

    Code Inist : 002B03L06. Création : 16/11/1999.