Although the number of homeless persons is increasing worldwide, studies delineating the health status of these persons according to various medical perspectives, including hepatology, are limited.
However, such studies are important for understanding the pathogenesis of diseases and their prevention.
Thirty homeless patients with hepatocellular carcinoma (HCC) and 15 with liver cirrhosis (LC) who were admitted to the Osaka Socio Medical Center Hospital during the past 6 years were analyzed clinicopathologically.
All were from the Airin district of Osaka City.
The patients with HCC had a history of long stay (mean : 25 years) in the district and many infectious opportunities and most of them were malnourished.
The main causes of liver disease in the patients with HCC were hepatitis C virus (HCV) (77%), alcohol abuse (73%), and the combination of HCV and alcohol abuse (50%). Serum HCV RNA concentration was 105.8±0.9 copies/50mul in the 21 HCC patients and 106.5±0.7 copies/50mul in the 14 LC patients (p<0.02).
Six HCC patients (20%) were positive for the GB virus C/Hepatitis G virus (GBV-C/HGV) RNA in association with HCV or hepatitis B virus (HBV).
Only 2 patients with HCC underwent the curative operations and most of the HCC cases were in progressed stages.
A long stay in a hygiene-poor environment increases the opportunity for infection in homeless people. (...)
Mots-clés Pascal : Carcinome hépatocellulaire, Pathogénie, Cirrhose, Foie, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Hépatite virale C, Virose, Infection, Facteur risque, Sans domicile fixe, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Hepatocellular carcinoma, Pathogenesis, Cirrhosis, Liver, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Viral hepatitis C, Viral disease, Infection, Risk factor, Homeless, Epidemiology, Human, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0291740
Code Inist : 002B30A01A2. Création : 16/11/1999.