Tissue levels of mercury determined in a deceased worker after occupational exposure.
To examine mercury (Hg) and selenium (Se) levels in autopsy samples from a thermometer worker who had been exposed over a long period to, and monitored for, mercury vapor.
Case report : Hg and Se levels were determined using radiochemical neutron activation analysis in a worker who had commited suicide 4 weeks after the end of 14 years of exposure and in an unexposed age-matched referent.
Histochemical staining of cerebellum was performed according to the method of Danscher and Schroder.
The Hg concentrations (wet weight) were 25 mug/g in the kidney cortex, 1.2 mug/g in the liver, 0.72 mug/g in the lung, 0.025 mug/g in the testis, and 0.014-0.018 mug/g in the cerebellum (gray matter, dentate nucleus, and white matter).
The Se level in the kidney cortex was high, 4.6 mug/g, whereas the concentration detected in the other tissue samples was normal.
Light microscopy of the cerebellum was normal, and no histochemical staining for mercury was observed.
Autopsy samples from the referent showed low Hg and Se levels consistent with other reports.
The observed kidney-Hg, which was 50-100 times higher than that occurring in the general population, is in agreement with previous sparse data from ongoing occupational exposure.
The high Se level detected in the kidney indicates coaccumulation with mercury. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Mercure, Sélénium, Thermomètre, Industrie, Autopsie, Accumulation biologique, Evaluation, Etude cas, Histologie, Rein, Encéphale, Histochimie, Homme
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Mercury, Selenium, Thermometer, Industry, Autopsy, Biological accumulation, Evaluation, Case study, Histology, Kidney, Brain (vertebrata), Histochemistry, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0290616
Code Inist : 002B03L05. Création : 16/11/1999.