Background Few studies have described the perinatal risks associated with infertility, other than for infertility treated by in-vitro fertilisation or gamete intrafallopian transfer.
The aim of this analysis was to estimate the risks of perinatal death associated with treated and untreated infertility.
Methods A population-based case-control study of perinatal deaths was carried out in Leicestershire Health District over the period 1990-94, during which 60922 babies were delivered.
Of these, 567 perinatal deaths were associated with 542 women. 972 mothers were randomly selected as controls.
Medical, obstetric, and social data were collected for cases and controls from the medical notes and interviews with the women.
The relative risks of perinatal death associated with treated and untreated infertility before the index pregnancy were estimated as odds ratios by means of unconditional logistic regression analysis.
Findings 65 (10%) of cases and 34 (3.5%) of the controls had infertility before the index pregnancy.
History of infertility in the index pregnancy, irrespective of treatment, increased the risk of perinatal death (odds ratio 2.9 [95% Cl 1.8-4.5]). The population attributable risk fraction for perinatal death related to infertility was 6.2% (3.4-9.0). 45 (54%) of the deaths, even in the untreated group, were associated with immaturity.
Compared with women without infertility, women with untreated infertility were at increased risk of perinatal death (3.3). (...)
Mots-clés Pascal : Stérilité femelle, Etude cas témoin, Association, Mortalité, Périnatal, Traitement, Facteur risque, Etiologie, Base donnée, Femelle, Homme, Appareil génital femelle pathologie
Mots-clés Pascal anglais : Female sterility, Case control study, Association, Mortality, Perinatal, Treatment, Risk factor, Etiology, Database, Female, Human, Female genital diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0289531
Code Inist : 002B20A04. Création : 16/11/1999.