Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts : correlations between airborne exposure and adduct levels.
Ethylene oxide (EO) and propylene oxide (PO) are important industrial chemicals.
Exposure to these directly acting mutagens may be monitored by determination of their adducts to hemoglobin (Hb).
This study establishes correlations between airborne concentrations of EO and PO and their Hb adducts in petrochemical workers.
In three different studies conducted during maintenance shutdown of petrochemical plants the external occupational exposure to EO and PO was assessed by personal air monitoring (PAM).
The internal exposure to EO and PO was concomitantly assessed by determination of N- (2-hydroxy-ethyl) valine (HOEtVal) and N- (3-hydroxypropyl) valine (HOPrVal) in blood samples of the operators using the N-alkyl-Edman degradation method.
In the first study, PAM was applied once a month at random over a period of 4 months.
Blood samples for Hb-adduct determination were collected at the end of this period.
No significant correlation was found between PAM and Hb-adduct data.
In the next two studies, PAM was applied to the operators during the entire shift on every working day during the shutdown.
Blood samples were collected before and immediately after the shutdown period.
Highly significant correlations were found between the increment in the concentration of HOEtVal and HOPrVal over this period and the total exposure to EO and PO, respectively. (...)
Mots-clés Pascal : Exposition professionnelle, Etude cas témoin, Médecine travail, Oxirane, Industrie pétrochimique, Homme, Surveillance biologique, Mutagène, Liquide biologique, Sang, Marqueur biologique, Hémoglobine, Adduit moléculaire, Teneur air ambiant, Oxirane(méthyl), Lieu travail, Evaluation, Relation dose réponse
Mots-clés Pascal anglais : Occupational exposure, Case control study, Occupational medicine, Ethylene oxide, Petrochemical industry, Human, Biological monitoring, Mutagen, Biological fluid, Blood, Biological marker, Hemoglobin, Molecular adduct, Ambient air concentration, Oxirane(methyl), Work place, Evaluation, Dose activity relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0289428
Code Inist : 002B03L06. Création : 16/11/1999.