Change in semen quality and sperm chromatin structure following occupational styrene exposure.
Organic solvents have been suspected to exert detrimental effects on human spermiogenesis.
Styrene, which is both mutagenic and neurotoxic, was selected as a suitable organic solvent for further assessment of a possible effect on semen quality and sperm DNA damage.
Subjects and methods
Semen samples were collected from 23 reinforced plastics workers at the time of employment and after 6 months of styrene exposure and from 21 nonexposed farmers.
Intra-individual changes in conventional semen parameters and sperm-DNA denaturation patterns were related to the internal dose of styrene exposure as measured by postshift urinary mandelic acid.
A statistically significant decline in sperm density was seen during styrene exposure from 63.5 to 46.0 million sperm/ml, whereas no decline was seen in the nonexposed subjects.
The total sperm count was almost halved from an initial value of 175 million sperm/ejaculate.
However, no relationship was apparent when the sperm parameters were related to internal levels of exposure.
However, an exposure-response relationship was shown for DNA-denaturation patterns, but the numbers were small.
A declining sperm count following styrene exposure is suggested. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Styrène, Solvant organique, Industrie matière plastique, Sperme pathologie, Toxicité, Homme, Mutagène, Etude cas témoin, Etude longitudinale, Comparaison intraindividuelle, Spermogramme, Chromatine, Relation dose réponse
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Styrene, Organic solvent, Plastics industry, Semen disorders, Toxicity, Human, Mutagen, Case control study, Follow up study, Intraindividual comparison, Sperm count, Chromatin, Dose activity relation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0289427
Code Inist : 002B03L04. Création : 16/11/1999.