A seroepidemiological study was conducted on a representative sample (n=3944) of the Spanish population to assess the immune status to diphtheria.
A total of 1907 men and 2037 women in the 5-59 years age range were stratified by sex and age (5-12,13 19. 20 - 29,30-39,40-49,50-59 years).
Concentrations of toxin antibodies were measured using a commercial ELISA kit.
Samples with titres >= 0.1 IU/ml were considered to show full protection.
Only 26% (95% CI : 25 - 28%) of the overall population studied was fully protected.
The highest number of subjects with uncertain or no protection was found in the 20 39 age group (>85%). The prevalence of fully protected subjects progressively declined from 51% for the 5-12 year age group, to 14% for the 30-39 year age group hereas it increased to 20% and 35% for the 40-49 and the 50-59 year age groups, respectively (p<0.0001).
These results stress the need to intensify vaccination programs in adolescents and adults with periodic booster doses of diphtheria toxoid.
Mots-clés Pascal : Corynebacterium diphtheriae, Corynebacteriaceae, Actinomycetes, Bactérie, Homme, Diphtérie, Bactériose, Infection, Epidémiologie, Programme sanitaire, Vaccination, Immunité, Immunoprotection, Anticorps, Sérologie, Prévalence, Espagne, Europe, Europe Sud
Mots-clés Pascal anglais : Corynebacterium diphtheriae, Corynebacteriaceae, Actinomycetes, Bacteria, Human, Diphtheria, Bacteriosis, Infection, Epidemiology, Sanitary program, Vaccination, Immunity, Immunoprotection, Antibody, Serology, Prevalence, Spain, Europe, Southern Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0288610
Code Inist : 002A05B11. Création : 16/11/1999.