To describe the frequency of self-reported fractures in a large population-based cohort of women with lupus, to compare the frequency of self-reported fractures between lupus patients and women of similar age in the general population by use of data from the 1994 National Health Interview Survey (NHIS), and to describe the associated risk factors for fracture in women with lupus.
This study is a secondary analysis of data collected to assess cardiovascular risk in women with lupus.
Fractures and associated risk factors were ascertained by self report in this retrospective cohort study of 702 living women with lupus who were followed up for 5,951 person-years.
Self-reported fractures were verified in a subset of patients.
A Weibull regression model was used to assess risk factors associated with time from lupus diagnosis to fracture in the univariate and multivariate analyses.
Age-specific standard morbidity ratios (SMRs) were calculated to determine whether fracture occurrence was greater than expected in women with lupus.
Eighty-six (12.3%) of 702 women reported at least 1 fracture following the diagnosis of lupus.
The sites of the first fracture were the leg (n=32), foot (n=16), arm (n=15), spine (n=9), rib (n=7), hip (n=2), pelvis (n=2), hand (n=1), shoulder (n=1), and finger (n=1). (...)
Mots-clés Pascal : Lupus érythémateux, Disséminé, Complication, Fracture, Os, Femelle, Epidémiologie, Fréquence, Facteur risque, Appareil circulatoire pathologie, Homme, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Système ostéoarticulaire pathologie, Traumatisme, Vaisseau sanguin pathologie, Cardiopathie, Maladie cardiovasculaire
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Complication, Fracture, Bone, Female, Epidemiology, Frequency, Risk factor, Cardiovascular disease, Human, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Diseases of the osteoarticular system, Trauma, Vascular disease, Heart disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0285293
Code Inist : 002B07. Création : 16/11/1999.