To determine the relationships between serum vitamin D metabolites, bone mass, and dietary calcium and phosphorus in a cohort of 510 healthy Danish perimenopausal women.
A population-based cross-sectional study.
A total of 510 healthy women aged 45-58 years, with amenorrhoea for 3-24 months.
None of the women was using hormone replacement therapy.
Measurements of total bone mineral content and regional bone mineral density were performed by dual-energy X-ray absorptiometry.
Analyses of serum levels of 25-OHD and 1,25- (OH) 2D, intact PTH, ionized calcium and phosphate, as well as biochemical markers of bone turnover in blood and urine.
Assessment of calcium and phosphorus intake using dietary records.
A consistent inverse relationship between serum 1,25- (OH) 2D and bone mineral content/density was found in whole-body mineral content (P=0.001), spine (P=0.005) and femoral neck (P<0.05).
There was a positive relationship between levels of 1,25- (OH) 2D and biochemical bone markers, indicating that high levels of 1,25- (OH) 2D are accompanied by increased bone turnover.
The dietary calcium : phosphorus ratio was inversely related to serum 1,25- (OH) 2D (P=0.04) and positively related to bone mineral density (P<0.0005).
No relationships could be detected between levels of PTH, serum ionized calcium and phosphate, and serum vitamin D metabolites. (...)
Mots-clés Pascal : Densité, Os, Masse osseuse, Vitamine D, Métabolisme, Métabolite, Phosphore, Calcium, Régime alimentaire, Postménopause, Epidémiologie, Corrélation, Homme, Femelle, Danemark, Europe, Système ostéoarticulaire, Ostéoporose
Mots-clés Pascal anglais : Density, Bone, Bone mass, Vitamin D, Metabolism, Metabolite, Phosphorus, Calcium, Diet, Postmenopause, Epidemiology, Correlation, Human, Female, Denmark, Europe, Osteoarticular system, Osteoporosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0284974
Code Inist : 002B15A. Création : 16/11/1999.