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  1. Relationships between bone mineral density, serum vitamin D metabolites and calcium : phosphorus intake in healthy perimenopausal women.

    Article - En anglais

    Objectives

    To determine the relationships between serum vitamin D metabolites, bone mass, and dietary calcium and phosphorus in a cohort of 510 healthy Danish perimenopausal women.

    Design

    A population-based cross-sectional study.

    Subjects.

    A total of 510 healthy women aged 45-58 years, with amenorrhoea for 3-24 months.

    None of the women was using hormone replacement therapy.

    Measurements

    Measurements of total bone mineral content and regional bone mineral density were performed by dual-energy X-ray absorptiometry.

    Analyses of serum levels of 25-OHD and 1,25- (OH) 2D, intact PTH, ionized calcium and phosphate, as well as biochemical markers of bone turnover in blood and urine.

    Assessment of calcium and phosphorus intake using dietary records.

    Results

    A consistent inverse relationship between serum 1,25- (OH) 2D and bone mineral content/density was found in whole-body mineral content (P=0.001), spine (P=0.005) and femoral neck (P<0.05).

    There was a positive relationship between levels of 1,25- (OH) 2D and biochemical bone markers, indicating that high levels of 1,25- (OH) 2D are accompanied by increased bone turnover.

    The dietary calcium : phosphorus ratio was inversely related to serum 1,25- (OH) 2D (P=0.04) and positively related to bone mineral density (P<0.0005).

    No relationships could be detected between levels of PTH, serum ionized calcium and phosphate, and serum vitamin D metabolites. (...)

    Mots-clés Pascal : Densité, Os, Masse osseuse, Vitamine D, Métabolisme, Métabolite, Phosphore, Calcium, Régime alimentaire, Postménopause, Epidémiologie, Corrélation, Homme, Femelle, Danemark, Europe, Système ostéoarticulaire, Ostéoporose

    Mots-clés Pascal anglais : Density, Bone, Bone mass, Vitamin D, Metabolism, Metabolite, Phosphorus, Calcium, Diet, Postmenopause, Epidemiology, Correlation, Human, Female, Denmark, Europe, Osteoarticular system, Osteoporosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0284974

    Code Inist : 002B15A. Création : 16/11/1999.