Evidence of gastrointestinal immune reactivity in patients with sarcoidosis.
The aim of the present study was to explore the frequency of clinical and serological manifestations of gastrointestinal immune reactivity in a large group of Swedish patients with sarcoidosis.
In patients with documented sarcoidosis, the presence of pernicious anaemia and coeliac disease was examined.
Antibodies to H+/K+ATPase, gliadin (AGA-IgA/IgG) and endomysium (IgA-EMA) were analysed.
In H+/K+ATPase antibody-positive patients, serum gastrin levels were measured and, when elevated, gastrointestinal biopsy was offered (biopsy performed in 6/9 patients) : biopsy was also offered to those with positive EMA or AGA of either class (biopsy performed in 8/12 patients).
Subjects from national and local studies were used as controls.
The patients were recruited at the Department of Pulmonary Medicine, and the study was conducted at the Department of Endocrinology, University of Lund, Malmö University Hospital, Malmö, Sweden.
Of all patients (n=89) with documented sarcoidosis attending the Department of Pulmonary Medicine between January 1980 and December 1991,78 [34 females and 44 males ; median age at the time of the study, 48 (range 22-81) years ; median observation time since the diagnosis of sarcoidosis, 120 (range 1-468) months] were examined.
Twenty-nine patients (37.2%) had signs of gastrointestinal immune reactivity.
H+/K+ATPase antibodies were detected in 19 patients (24.4 vs. 4% in controls, P=0.00015). (...)
Mots-clés Pascal : Sarcoïdose, Réponse immune, Gastrointestinal, Epidémiologie, Physiopathologie, Complication, Prévalence, Homme, Suède, Europe, Maladie système, Appareil digestif pathologie
Mots-clés Pascal anglais : Sarcoidosis, Immune response, Gastrointestinal, Epidemiology, Pathophysiology, Complication, Prevalence, Human, Sweden, Europe, Systemic disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0284709
Code Inist : 002B07. Création : 16/11/1999.