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  1. Age at natural menopause and total mortality and mortality from ischemic heart disease : The Adventist health study.

    Article - En anglais

    We studied the relationship between age at natural menopause and total mortality as well as mortality from ischemic heart disease in a cohort of 6182 California Seventh-Day Adventist women who reported a natural menopause.

    During follow-up from 1976 through 1988, there were 1831 deaths.

    A total of 308 deaths due to ischemic heart disease occurred in women who denied ischemic heart disease at start of follow-up.

    An early menopause was associated with increased total mortality (P value for linear trend<0.001) and ischemic heart disease mortality (P value for linear trend=0.03).

    This relationship could not be explained by possible confounding variables.

    Our results support the hypothesis that an early natural menopause (35-40 years old) increases the risk of ischemic heart disease.

    There is, however, also some evidence of increased risk of ischemic heart disease in women with a very late menopause (>55 years), particularly in women who never have used postmenopausal estrogens.

    Mots-clés Pascal : Mortalité, Ménopause, Oestrogène, Age, Infarctus, Myocarde, Epidémiologie, Facteur risque, Homme, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie

    Mots-clés Pascal anglais : Mortality, Menopause, Estrogen, Age, Infarct, Myocardium, Epidemiology, Risk factor, Human, Cardiovascular disease, Coronary heart disease, Myocardial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0284638

    Code Inist : 002B12A03. Création : 16/11/1999.