We studied the relationship between age at natural menopause and total mortality as well as mortality from ischemic heart disease in a cohort of 6182 California Seventh-Day Adventist women who reported a natural menopause.
During follow-up from 1976 through 1988, there were 1831 deaths.
A total of 308 deaths due to ischemic heart disease occurred in women who denied ischemic heart disease at start of follow-up.
An early menopause was associated with increased total mortality (P value for linear trend<0.001) and ischemic heart disease mortality (P value for linear trend=0.03).
This relationship could not be explained by possible confounding variables.
Our results support the hypothesis that an early natural menopause (35-40 years old) increases the risk of ischemic heart disease.
There is, however, also some evidence of increased risk of ischemic heart disease in women with a very late menopause (>55 years), particularly in women who never have used postmenopausal estrogens.
Mots-clés Pascal : Mortalité, Ménopause, Oestrogène, Age, Infarctus, Myocarde, Epidémiologie, Facteur risque, Homme, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie
Mots-clés Pascal anglais : Mortality, Menopause, Estrogen, Age, Infarct, Myocardium, Epidemiology, Risk factor, Human, Cardiovascular disease, Coronary heart disease, Myocardial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0284638
Code Inist : 002B12A03. Création : 16/11/1999.