Inactivation of Cryptosporidium parvum oocyst infectivity by disinfection and sterilization processes.
Cryptosporidium parvum is a common cause of self-limited gastroenteritis in the normal host but may cause severe disease in immunocompromised persons.
Person-to-person transmission has been well documented in households, child care centers, and hospitals.
Because contaminated environmental surfaces and medical devices such as endoscopes may play a role in disease transmission, we studied the susceptibility of C parvum to chemical agents commonly used for disinfection and evaluated the efficacy of sterilization processes.
Seven disinfectants were studied at their use dilution using a suspension test.
Antimicrobial activity was assessed with the use of a cell infectivity assay.
All sterilization processes tested (steam, ethylene oxide, Sterrad 100) inactivated 3 logs or greater of C parvum.
The only liquid disinfectant/sterilant able to inactivate greater than 3 logs of C parvum was 6% and 7.5% hydrogen peroxide.
Agents that did not completely inactivate C parvum included hydrogen peroxide at lower concentrations or exposure times, peracetic acid, sodium hypochlorite, a phenolic, a quaternary ammonium compound, 2% glutaraldehyde, and ortho-phthalaldehyde.
Most high-level disinfectants used on endoscopes have limited efficacy against C parvum.
However, the infectivity of C parvum on dry surfaces decreases rapidly. (...)
Mots-clés Pascal : Endoscopie, Appareil digestif, Complication, Bactériose, Infection, Cryptosporidium parvum, Apicomplexa, Protozoa, Transmission homme homme, Contamination, Equipement, Prévention, Désinfection, Stérilisation, Evaluation performance, Homme, Infection opportuniste
Mots-clés Pascal anglais : Endoscopy, Digestive system, Complication, Bacteriosis, Infection, Cryptosporidium parvum, Apicomplexa, Protozoa, Transmission from man to man, Contamination, Equipment, Prevention, Disinfection, Sterilization, Performance evaluation, Human, Opportunistic infection
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0280462
Code Inist : 002B24E08. Création : 16/11/1999.