Cohort analysis of treatment outcomes is the most informative technique to evaluate the tuberculosis (TB) control programme.
The aim of the study was to assess treatment outcomes comparing the smear-versus the culture-based methods, using data on TB patients treated under programme conditions in Italy.
This was a prospective monitoring study based on the standardized collection of forms from a representative sample of Italian TB Units.
The forms, with individual data, were reviewed and analysed on a quarterly basis according to the principles of cohort analysis, using both the smear-and culture-based methods.
The complete bacteriological profile of patients was analysed at diagnosis and at completion of treatment.
Nine hundred and ninety-two TB cases were notified.
Among 681 pulmonary cases, 368 cases were culture-confirmed at diagnosis (333 new and 35 retreatment cases, 293 being sputum smear positive, 79.6%). At the end of treatment, out of the 333 new culture-confirmed cases, 136 (40.8%) were defined « cured » using the culture-based method and 108 (32.4%) using the smear-based method (p<0.05, x2 test).
The culture-based method is the recommended tool to evaluate pulmonary tuberculosis treatment results.
Culture allows a more precise definition of a « cured » patient in both sputum smear positive and negative tuberculosis cases.
Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Italie, Europe, Homme, Antituberculeux, Traitement, Chimiothérapie, Efficacité traitement, Etude multicentrique, Etude comparative, Expectoration, Frottis, Culture microorganisme, Exploration, Technique, Antibiotique
Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Italy, Europe, Human, Antituberculous agent, Treatment, Chemotherapy, Treatment efficiency, Multicenter study, Comparative study, Sputum, Smear, Microorganism culture, Exploration, Technique, Antibiotic
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0279951
Code Inist : 002B05B02O. Création : 16/11/1999.