Postmenopausal hormone therapy and the risk of Colorectal cancer : A review and meta-analysis.
Colorectal cancer is the fourth most common cancer and the second leading cause of cancer death in the United States.
Accumulating evidence indicates that postmenopausal hormone therapy may reduce the risk of colorectal cancer in women.
Through MEDLINE computer searches (January 1966 to September 1998) and a review of references, we identified English-language articles with quantitative data on the relation of postmenopausal hormone therapy to colorectal cancer.
We reviewed the studies and made summary estimates of relative risks (RR) by weighting the results of each study in proportion to its precision, using a general variance-based, fixed-effects model.
In our meta-analysis of 18 epidemiologic studies of postmenopausal hormone therapy and colorectal cancer, we found a 20% reduction [RR=0.80,95% confidence interval (Cl), 0.74 to 0.86] in risk of colon cancer and a 19% decrease (RR=0.81,95% CI, 0.72 to 0.92) in the risk of rectal cancer for postmenopausal women who had ever taken hormone therapy compared with women who never used hormones.
Much of the apparent reduction in colorectal cancer was limited to current hormone users (RR=0.66,95% Cl, 0.59 to 0.74).
Observational studies suggest a reduced risk ofcolorectal cancer among women taking postmenopausal hormones.
There is biologic evidence to support this association.
Mots-clés Pascal : Carcinome, Côlon, Rectum, Hormone, Traitement substitutif, Association, Postménopause, Epidémiologie, Prévention, Facteur risque, Article synthèse, Métaanalyse, Analyse statistique, Femelle, Homme, Etats Unis, Amérique du Nord, Amérique, Revue bibliographique, Tumeur maligne, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Hormone stéroïde sexuelle, Appareil génital femelle
Mots-clés Pascal anglais : Carcinoma, Colon, Rectum, Hormone, Replacement therapy, Association, Postmenopause, Epidemiology, Prevention, Risk factor, Review, Metaanalysis, Statistical analysis, Female, Human, United States, North America, America, Bibliographic review, Malignant tumor, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Sex steroid hormone, Female genital system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0279087
Code Inist : 002B02O. Création : 16/11/1999.