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  1. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly.

    Article - En anglais

    PURPOSE 

    To investigate whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people.

    SUBJECTS AND METHODS 

    A sample of 1,293 healthy, nondisabled participants in the Iowa 65+Rural Health Study was followed prospectively for a mean of 4.6 years.

    Plasma interleukin-6 and C-reactive protein levels were measured in specimens obtained from 1987 to 1989.

    RESULTS 

    Higher interleukin-6 levels were associated with a twofold greater risk of death [relative risk (RR) for the highest quartile (>3.19 pg/mL) compared with the lowest quartile of 1.9 [95% confidence interval, CI, 1.2 to 3.1]). Higher C-reactive protein levels (>2.78 mg/L) were also associated with increased risk (RR=1.6 ; CI, 1.0 to 2.6).

    Subjects with elevation of both interleukin-6 and C-reactive protein levels were 2.6 times more likely (CI, 1.6 to 4.3) to die during follow-up than those with low levels of both measurements.

    Similar results were found for cardiovascular and noncardiovascular causes ofdeath, as well as when subjects were stratified by sex, smoking status, and prior cardiovascular disease, and for both early (<2.3 years) and later follow-up.

    Results were independent of age, sex, body mass index, and history of smoking, diabetes, and cardiovascular disease, as well as known indicators of inflammation including fibrinogen and albumin levels and white blood cell count. (...)

    Mots-clés Pascal : Mortalité, Personne âgée, Homme, Facteur risque, Interleukine 6, Biologie clinique, Association, Protéine C réactive, Mesure comparative, Evaluation, Cytokine

    Mots-clés Pascal anglais : Mortality, Elderly, Human, Risk factor, Interleukin 6, Clinical biology, Association, C reactive protein, Comparison measurement, Evaluation, Cytokine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0279031

    Code Inist : 002B24O14. Création : 16/11/1999.