Utilization of developmental basic science principles in the evaluation of reproductive risks from pre-and postconception environmental radiation exposures.
Symposium for the 1997 Annual Meeting of the NCRP, "The Pre-and Postconception Reproductive Effects of Exposures to Radiation". Crystal City, VA, USA, 1997/04/02.
The subject of the reproductive toxicity of various forms of radiation can be anxiety provoking to the public on two accounts, since reproductive failure engenders an unusual level of guilt and anger in the affected families, and radiation effects are misunderstood and feared by the public.
Reproductive problems include an array of genetic and acquired diseases affecting parents and their offspring.
Many of these problems are associated with the risk of being induced by preconception and/or postconception exposures to environmental agents.
For the various forms of radiation, namely, ionizing radiation, ultrasound, low-frequency electromagnetic fields (EMF), and microwaves, the potential for producing reproductive effects varies considerably with the form of « radiation » and, of course, the dose.
Whether the exposure occurs preconceptionally or postconceptionally is another major consideration.
In evaluating the actual reproductive risks, we rely on accurate dosimetry and information obtained in epidemiological studies and animal studies.
Epidemiological studies must demonstrate consistency of the reproductive finding, and animal studies should be designed to add to the findings of the epidemiological studies.
Most importantly, the conclusions must not contradict the basic principles of teratology, genetics, and reproductive biology, and they should be biologically plausible.
But frequently important basic science principles are ignored in the evaluation process. (...)
Mots-clés Pascal : Rayonnement ionisant, Méthode étude, Evaluation, Santé et environnement, Hyperfréquence, Période activité génitale, Toxicité, Animal, Article synthèse, Reproduction pathologie, Gestation, Trouble développement, Epidémiologie, Homme, Facteur risque, Ultrason, Tératogène, Relation dose réponse, Effet biologique, Exposition, Accident, Etude comparative
Mots-clés Pascal anglais : Ionizing radiation, Investigation method, Evaluation, Health and environment, Microwave, Sexually active period, Toxicity, Animal, Review, Reproduction diseases, Pregnancy, Developmental disorder, Epidemiology, Human, Risk factor, Ultrasound, Teratogen, Dose activity relation, Biological effect, Exposure, Accident, Comparative study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0278862
Code Inist : 002A08F02. Création : 16/11/1999.