There is evidence for genetic predisposition to diabetic nephropathy in type 1 diabetic patients.
However, there are few studies on type 2 diabetic patients, and most of those have been conducted on ethnic minorities or Caucasian individuals.
The aim of this study was to ascertain the presence of an inherited predisposition to diabetic nephropathy in a sample of Brazilian type 2 diabetic patients.
Families with two or more type 2 diabetic siblings were identified.
Subjects with the longest duration of known diabetes were considered probands.
Some 90 probands and their 107 diabetic siblings were studied.
Urinary albumin excretion rate was measured in a sterile 24-h urine sample on at least three different occasions.
Probands and siblings were classified according to urinary albumin excretion rate as normo- (<20 mug/min), micro- (20-200 mug/min), or macroalbuminuric (>200 mug/min).
Patients with end-stage renal disease were included in the macroalbuminuric group.
Macroalbuminuria was identified in 5.2% of the siblings of normoalbuminuric probands and in 24.1% of the siblings of macroalbuminuric probands (P=0.024).
In multiple logistic regression, the presence of diabetic nephropathy in probands (micro-or macroalbuminuria and end-stage renal disease) was significantly associated with the presence of sibling diabetic nephropathy (odds ratio=3.75,95% CI=1.36-10.40, P=0.011) adjusted for proband fasting plasma glucose and diabetes duration. (...)
Mots-clés Pascal : Etude familiale, Prédisposition, Prévalence, Diabète non insulinodépendant, Complication, Néphropathie, Endocrinopathie, Appareil urinaire pathologie, Rein pathologie, Homme, Origine ethnique, Brésil, Amérique du Sud, Amérique, Brésilien
Mots-clés Pascal anglais : Family study, Predisposition, Prevalence, Non insulin dependent diabetes, Complication, Nephropathy, Endocrinopathy, Urinary system disease, Kidney disease, Human, Ethnic origin, Brazil, South America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0275215
Code Inist : 002B21E01B. Création : 16/11/1999.