Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts.
Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation.
Objectives Evaluation of total IgE and Phadiatop status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization.
Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens).
Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category.
Results (1) Pre-employment :
Four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop positive.
Levels of total IgE>100 kU/L, present in 16 subjects were associated with positive Phadiatop status and race. (2) During employment : Phadiatop status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P<=0.0001).
Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P=0.0015). (...)
Mots-clés Pascal : Allergie, Allergène, Platine composé, IgE, Exposition professionnelle, Dépistage, Valeur prédictive, Surveillance biologique, Toxicité, Homme, Immunopathologie, Médecine travail, Biologie clinique
Mots-clés Pascal anglais : Allergy, Allergen, Platinum compound, IgE, Occupational exposure, Medical screening, Predictive value, Biological monitoring, Toxicity, Human, Immunopathology, Occupational medicine, Clinical biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0273637
Code Inist : 002B03L05. Création : 16/11/1999.