Patients with primary biliary cirrhosis (PBC) may be at increased risk for malignancies.
Several studies have addressed the risk of specific malignancies ; however, there is little information about overall incidences of malignancies in these patients.
We hypothesize that these patients may be at an increased risk for cancer.
We performed a retrospective chart review evaluating patients with the diagnosis of PBC and malignancies.
We reviewed records of patients with PBC presenting to the Mayo Clinic between 1976 and 1985.
The diagnosis of PBC was made using evidence of cholestasis, positive antimitochondrial antibody titers and liver biopsy findings consistent with PBC.
The incidence of malignancies were then compared with published data by the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute.
Of the 1,692 patients with PBC in the Mayo Clinic data base, 114 patients were identified with primary cancer.
The number of malignancies was higher than would be anticipated by chance alone ; with 93 observed versus 62.4 expected events (P<. 001).
Hepatobiliary malignancies had a relative risk of 46 (P<. 0001) for women and 55 (P<. 0001) in men.
There was a dramatic increased risk for development of hepatobiliary malignancies.
PBC patients might benefit from more aggressive surveillance for hepatobiliary malignancies during their lifetime.
Mots-clés Pascal : Cirrhose biliaire, Primitif, Incidence, Tumeur maligne, Complication, Indication, Renforcement, Surveillance, Etude statistique, Homme, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Immunopathologie, Maladie autoimmune, Cancérologie
Mots-clés Pascal anglais : Biliary cirrhosis, Primitive, Incidence, Malignant tumor, Complication, Indication, Reinforcement, Surveillance, Statistical study, Human, Digestive diseases, Hepatic disease, Biliary tract disease, Immunopathology, Autoimmune disease, Cancerology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0271805
Code Inist : 002B13C01. Création : 16/11/1999.