The reformulation of epidemiological prevalence rates as evolutionary frequency rates puts medical genetics within an explicit framework of Darwinian theory.
Yet an enduring and still current assumption of genomic medicine is that genes associated with disease are necessarily maladapted.
Indeed, it seems it could hardly be otherwise.
However, evolutionary epidemiology has begun to uncover important and surprising counter-exemplary case-studies.
Thus, the present aim is to first outline this emerging sub-discipline of'evolutionary epidemiology'Then, a major psychopathological syndrome-manic-depression-is examined in some detail within the purview of evolutionary epidemiology.
Its medical genetics are those of an adaptive polymorphism in the human genome.
Hence, genes associated with what is now a major public health problem accrued as they conferred selective advantage in phylogeny.
Why should manic-depressive etiogenes have been selected ?
A preliminary anatomic-functional model, assembled from facts of human paleoneuropsychiatry, more adequately contextualises manic-depressive genomics and phenotypy.
In this model, manic-depression finds its heuristic origins in a hierarchy of behavioural strategies stabilised in phylogeny and embedded at serial levels in the brain (Hawk-Dove ESS). (...)
Mots-clés Pascal : Trouble bipolaire, Théorie, Evolution biologique, Epidémiologie, Prévalence, Santé mentale, Homme, Trouble humeur
Mots-clés Pascal anglais : Bipolar disorder, Theory, Biological evolution, Epidemiology, Prevalence, Mental health, Human, Mood disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0270636
Code Inist : 002B18C07C. Création : 16/11/1999.