Risk of hepatitis C virus transmission to surgeons and nurses from infected patients : model-based estimates in France.
The aim of this study was to estimate the annual number of cases of hepatitis C virus transmission from infected patients to uninfected surgeons or nurses due to percutaneous injury during invasive procedures Methods :
The risk of transmission was estimated using a model involving three probabilities : A, that a health care worker sustains at least one percutaneous injury during a procedure ;
B, that 1 to 10% of patients are seropositive for hepatitis C virus ;
and C, that infection by this virus is transmitted to the Health Care Worker after such exposure.
Probability A was estimated from the results of 2 French multicentric prospective trials.
Probability C was estimated from the results of 9 international prospective studies.
A ten-fold decreased risk was assumed for surgeons who wear gloves and use solid-bore suture needles.
During a single procedure, the estimated probability of hepatitis C virus transmission from an infected patient to an uninfected surgeon ranged from 4.2x10-5% to 4.2x10-4%, and from 2.98x10-6% to 2.98x10-5% to an uninfected nurse.
For surgeons, the estimated annual cumulative risk of occupational infection ranged from 0.01% to 0.1% (1 in 10000 to 1 in 1000), and for nurses from 0.0054% to 0.054% (1 in 18700 to 1 in 1900).
Between 2 and 21 surgeons out of a total 20000 are estimated to acquire occupationally-related hepatitis C virus infection, and between 16 and 167 nurses out of a total 300 000. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Evaluation, Risque, Contamination, Médecin, Infirmier, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Pratique professionnelle, Exposition professionnelle, Modèle mathématique, Epidémiologie, Homme, France, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Evaluation, Risk, Contamination, Physician, Nurse, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Professional practice, Occupational exposure, Mathematical model, Epidemiology, Human, France, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0270532
Code Inist : 002B30A01C. Création : 16/11/1999.