Background Epidemiological studies indicate a protective effect of postmenopausal oestrogen therapy on the risk of osteoporotic fractures.
Whether premenopausal oestrogen exposure in the form of oral contraceptives also reduces the risk of osteoporotic fractures remains uncertain.
Method We did a population-based case control study of hip fracture among Swedish postmenopausal women, 50-81 years of age, through mailed questionnaires and telephone interviews.
Of those women who were eligible, 1327 (82.5%) cases and 3312 (81.6%) randomly selected controls responded.
Findings 130 (11.6%) cases and 562 (19.1%) controls reported ever-use of oral contraceptives.
Ever-use of oral contraceptives was associated with a 25% reduction in hip fracture risk (odds ratio 0.75 [95% Cl 0.59-0.96]). Women who had ever used a high-dose pill (equivalent to >=50 mug ethinylestradiol per tablet) had a 44% lower risk for hip fracture than never-users (0.56 [0.42-0.75]). No overall trend was observed with duration of oral-contraceptive use, or time since last use.
However, when making comparisons with women who have never used oral contraceptives, the odds ratios for hip-fracture were 0.69 (0.51-0.94) for use after age 40,0.82 (0.57-1.16) for use at ages 30-39, and 1.26 (0.76-2.09) for use before age 30. (...)
Mots-clés Pascal : Contraception, Voie orale, Postménopause, Fracture, Hanche, Facteur risque, Etude cas témoin, Questionnaire, Femelle, Prévention, Homme, Suède, Europe, Préménopause, Chimiothérapie, Appareil génital femelle, Système ostéoarticulaire pathologie, Traumatisme
Mots-clés Pascal anglais : Contraception, Oral administration, Postmenopause, Fracture, Hip, Risk factor, Case control study, Questionnaire, Female, Prevention, Human, Sweden, Europe, Premenopause, Chemotherapy, Female genital system, Diseases of the osteoarticular system, Trauma
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0270350
Code Inist : 002B02P. Création : 16/11/1999.