Here we present the analysis of deformations observed in a series of 26,810 consecutive infants with congenital defects.
We observed that 3.88% of these infants had deformations, for a prevalence figure of 0.07% live-born infants.
From the present study we can conclude that there are three different types of deformation sequences :
one with polyhydramnios, thin skin without dermal ridges, hypotonia, and multiple deformations (hypokinesia sequence), which is most often due to intrinsic problems ;
another with oligohydramnios, redundant thick skin, and multiple deformations, which can be produced by intrinsic or extrinsic factors ;
and the third, with normal amniotic fluid volume, which is due to compression of different causes.
Deformations of extrinsic cause are more frequently isolated defects and have a better prognosis, while deformations of intrinsic origin are more frequently associated with other congenital anomalies and, generally, have a poor prognosis.
Mots-clés Pascal : Nourrisson, Homme, Phénotype, Exploration, Déformation, Congénital, Epidémiologie, Espagne, Europe, Pathogénie, Physiopathologie, Malformation, Maladie congénitale
Mots-clés Pascal anglais : Infant, Human, Phenotype, Exploration, Deformation, Congenital, Epidemiology, Spain, Europe, Pathogenesis, Pathophysiology, Malformation, Congenital disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0270331
Code Inist : 002B23A. Création : 16/11/1999.