Background Reye's syndrome is characterized by encephalopathy and fatty degeneration of the liver, usually after influenza or varicella.
Beginning in 1980, warnings were issued about the use of salicylates in children with those viral infections because of the risk of Reye's syndrome.
Methods To describe the pattern of Reye's syndrome in the United States, characteristics of the patients, and risk factors for poor outcomes, we analyzed national surveillance data collected from December 1980 through November 1997.
The surveillance system is based on voluntary reporting with the use of a standard case-report form.
Results From December 1980 through November 1997 (surveillance years 1981 through 1997), 1207 cases of Reye's syndrome were reported in patients less than 18 years of age.
Among those for whom data on race and sex were available, 93 percent were white and 52 percent were girls.
The number of reported cases of Reye's syndrome declined sharply after the association of Reye's syndrome with aspirin was reported.
After a peak of 555 cases in children reported in 1980, there have been no more than 36 cases per year since 1987.
Antecedent illnesses were reported in 93 percent of the children, and detectable blood salicylate levels in 82 percent.
The overall case fatality rate was 31 percent.
The case fatality rate was highest in children under five years of age (relative risk, 1.8 ; 95 percent confidence interval, 1.5 to 2. (...)
Mots-clés Pascal : Reye syndrome, Epidémiologie, Facteur risque, Homme, Etats Unis, Amérique du Nord, Amérique, Glucide, Enregistrement donnée, Appareil digestif pathologie, Foie pathologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Métabolisme pathologie, Enzymopathie
Mots-clés Pascal anglais : Reye syndrome, Epidemiology, Risk factor, Human, United States, North America, America, Carbohydrate, Data logging, Digestive diseases, Hepatic disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Metabolic diseases, Enzymopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0265713
Code Inist : 002B13C03. Création : 16/11/1999.