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  1. From research to practice : Use of short course zidovudine to prevent mother-to-child HIV transmission in the context of routine health care in northern Thailand.

    Article - En anglais

    Thailand has made remakable progress in battling the HIVepidemic, as the decreases in HIV prevalence and changes in sexual behavior attest.

    Yet, in Phayao, a northern province severely affected by HIV, approximately 280 HIV-infected women, or 5% of all pregnant women, gave birth to an estimated 70 infected children in 1997.

    As many of these infants die within their first year of life, the infant mortality rate is on the rise after years of decline.

    The province, however, responded quickly to this crisis.

    Since July 1997, the Ministry of Public Health (MOPH) offers through Phayao's seven public hospitals a short regimen of zidovudine to all consenting HIV-infected women to prevent mother-to-child transmission of the virus.

    The overall prophylactic coverage for the province reached 68% of all HIV-infected pregnant women in the fourth quarter of 1997, either through the MOPH program or through the North Thailand Perinatal HIV Prevention Trial, the parallel clinical trial conducted by the MOPH and the Ministry of University Affairs.

    Analysis of the data collected showed that compliance to the intervention was excellent, around 90%. This was achieved at an additional cost of US$ 0.13 per capita per year, affordable even in the context of the economic crisis, and represents less than 1% of public health expenditures in Thailand.

    The cost per Disability Adjusted Life Years saved is approximately US$35, making it highly cost-effective. (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Prévention, Transmission verticale, Traitement, Chimiothérapie, Zidovudine, Homme, Femelle, Thaïlande, Asie, Protocole thérapeutique, Pyrimidine nucléoside, Didésoxynucléoside, Immunopathologie, Immunodéficit, Antiviral

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Prevention, Vertical transmission, Treatment, Chemotherapy, Zidovudine, Human, Female, Thailand, Asia, Therapeutic protocol, Pyrimidine nucleoside, Dideoxynucleoside, Immunopathology, Immune deficiency, Antiviral

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0263321

    Code Inist : 002B05C02D. Création : 16/11/1999.