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  1. Reduction in the incidence of methicillin-resistant Staphylococcus aureus and ceftazidime-resistant Klebsiella pneumoniae following changes in a hospital antibiotic formulary.

    Article - En anglais

    In 1995, changes in our hospital formulary were made to limit an outbreak of vancomycin-resistant enterococci and resulted in decreased usage of cephalosporins, imipenem, clindamycin, and vancomycin and increased usage of bêta-lactam/bêta-lactamase-inhibitor antibiotics.

    In this report, the effect of this formulary change on other resistant pathogens is described.

    Following the formulary change, there was a reduction in the monthly number (mean ± SD) of patients with methicillin-resistant Staphylococcus aureus (from 21.9 ± 8.1 to 17.2 ± 7.2 patients/1,000 discharges ; P=03) and ceftazidime-resistant Klebsiella pneumoniae (from 8.6 ± 4.3 to 5.7 ± 4.0 patients/1,000 discharges ; P=02).

    However, there was an increase in the number of patients with cultures positive for cefotaxime-resistant Acinetobacter species (from 2.4 ± 2.2 to 5.4 ± 4.0 patients/1,000 discharges ; P=02).

    Altering an antibiotic formulary may be a possible mechanism to contain the spread of selected resistant pathogens.

    However, close surveillance is needed to detect the emergence of other resistant pathogens.

    Mots-clés Pascal : Staphylococcie, Bactériose, Infection, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bactérie, Klebsiella pneumoniae, Enterobacteriaceae, Méthode, Formule imprimée, Choix, Antibiotique, Antibactérien, Incidence, Hôpital, Souche hospitalière, Infection nosocomiale, Epidémiologie, Résistance, Efficacité, Souche résistante méticilline, souche resistante ceftazidime

    Mots-clés Pascal anglais : Staphylococcal infection, Bacteriosis, Infection, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bacteria, Klebsiella pneumoniae, Enterobacteriaceae, Method, Printed form, Choice, Antibiotic, Antibacterial agent, Incidence, Hospital, Hospital strain, Nosocomial infection, Epidemiology, Resistance, Efficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0262732

    Code Inist : 002B30A01C. Création : 16/11/1999.