Glutathione S-transferase (GST) M1 and GST T1 genotypes and hematopoietic effects of benzene exposure.
This study investigated whether or not the genotypes glutathione S-transferase 0 (GST T1) and mu (GST Ml) correlated with low white blood cell (WBC) count found in benzene exposed workers.
We found that individuals with genotypes positive for both GST T1 and GST Ml showed the highest prevalence of low WBC [odds ratio (OR)=4.67, P=0.046,95% confidence interval (CI)=1.02-24.15] when the benzene exposure was high.
Multiple logistic regression showed that benzene exposure (OR=2.81, P=0.062,95% CI=0.96-8.30) was associated with increased OR on low WBC and interactions between the benzene exposure and the genotype of GST Tl were also observed.
These observations suggest that GST T1 and GST Ml may play important roles in the biotransformation of benzene, the effect which leads to its hematotoxicity.
Mots-clés Pascal : Benzène, Médecine travail, Toxicité, Hématopoïèse, Hématite, Anémie, Exposition professionnelle, Homme, Taiwan, Asie, Corrélation, Prédisposition, Génotype, Enzyme, Isozyme, Détection, Taux, Hémopathie, Glutathion S-tranférase
Mots-clés Pascal anglais : Benzene, Occupational medicine, Toxicity, Hematopoiesis, Hematite, Anemia, Occupational exposure, Human, Taiwan, Asia, Correlation, Predisposition, Genotype, Enzyme, Isozyme, Detection, Rate, Hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0260040
Code Inist : 002B03L06. Création : 16/11/1999.