Seroprevalence of Helicobacter pylori, incidence of gastric cancer, and peptic ulcer-associated hospitalizations in a Canadian Indian population.
The living conditions of many aboriginal communities in Canada may place their residents at risk for H. pylori infection.
Our aims were to determine :
(1) the seroprevalence of H. pylori in a traditional Indian community, (2) the clinical relevance of H. pylon infection in this population, and (3) if H. pylori could be identified by polymerase chain reaction from the local water.
A demographic questionnaire was administered, and blood was collected from subjects in an Indian community in northwestern Manitoba.
The serum was analyzed by ELISA for IgG to H. pylori and to CagA.
ABO and Lewis antigens were tested.
Age-adjusted incidence of gastric cancer and of hospitalizations associated with diagnoses of peptic ulcer were determined for the Indian and non-Indian Manitoba population in the years 1989-1993.
Nested PCR was performed on lake water using H. pylori-specific primers and the amplicons probed with an internal Dig-labeled probe.
Three hundred six (59%) of approximately 518 individuals who were resident in the community at the time of the study were enrolled.
The ELISA for H. pylori was positive in 291 (95%). There was no association between H. pylori seropositivity and age, sex, gastrointestinal complaints, medications, housing characteristics, and ABO or Lewis antigen status.
CagA was positive in 84.5% of infected subjects. (...)
Mots-clés Pascal : Carcinome, Estomac, Gastrite, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Ulcère, Gastroduodénal, Effet environnement, Mode de vie, Incidence, Déterminisme génétique, Origine ethnique, Epidémiologie, Homme, Indien, Tumeur maligne, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie, Antigène cagA
Mots-clés Pascal anglais : Carcinoma, Stomach, Gastritis, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Ulcer, Gastroduodenal, Environmental effect, Life style, Incidence, Genetic determinism, Ethnic origin, Epidemiology, Human, Indian, Malignant tumor, Digestive diseases, Gastric disease, Intestinal disease, Cytotoxin-associated antigen
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0259874
Code Inist : 002B13B01. Création : 16/11/1999.