Cotinine in meconium indicates risk for early respiratory tract infections.
Passive Smoking & Children : Clinical & Experimental Forums. International Academic Symposium. Essen, DEU, 1998/08/25.
1 In order to identify potential risks for lower respiratory tract symptoms during early infancy, the concentration ofcotinine was measured in meconium of 91 new-borns as a parameter of prenatal exposure to tobacco, and a questionnaire was performed with parents at birth.
Infants were followed up for the first year of life by monthly telephone interviews. 2 Lower respiratory tract infections during the first 6 months of life were associated with a high concentration of cotinine in meconium (cotinine higher than median vs lower than median ; odds ratio 4.9,95% confidence interval 1.2 to 20.3), while none ofthe other variables tested including selfreport of parental, prenatal or postnatal tobacco consumption, parents history of atopy, maternal age, presence of siblings, socio-economic status, duration of gestation, birth weight, gender, and duration of breast feeding were identified as independent risks.
The occurrence of a lower respiratory tract infection during the first 6 months of life was predicted correctly in 77% of the infants by a cotinine excretion in meconium exceeding the group median. 3 In conclusion, quantification of cotinine in meconium is preferred to historical parameters as an estimate of the risk for early respiratory tract infections.
Mots-clés Pascal : Tabagisme passif, Toxicité, Epidémiologie, Appareil respiratoire pathologie, Facteur risque, Méconium, Détection, Cotinine, Homme, Nouveau né, Prédiction, Tabagisme
Mots-clés Pascal anglais : Passive smoking, Toxicity, Epidemiology, Respiratory disease, Risk factor, Meconium, Detection, Cotinine, Human, Newborn, Prediction, Tobacco smoking
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0259683
Code Inist : 002B03E. Création : 16/11/1999.