Epidemic Serogroup B meningococcal Disease in Oregon : The evolving epidemiology of the ET-5 strain.
Context In 1993, Oregon's incidence of serogroup B meningococcal disease began to rise because of a highly clonal group of strains designated enzyme type 5 (ET-5), the first such increase observed in the United States.
Objective To evaluate the impact that the ET-5 strain has had on the epidemiology of meningococcal disease in Oregon.
Design and Setting Epidemiologic analysis of surveillance data on Oregon meningococcal disease cases from 1987 through 1996 and multilocus enzyme electrophoresis typing of serogroup B isolates from June 1993 through April 1995 and from April through June 1996.
Patients A total of 836 persons with invasive meningococcal disease.
Main Outcome Measures Disease frequency and clonality of strains.
Results Serogroup B disease incidence rates more than doubled from the preepidemic period in 1987-1992 (1.0 case per 100 000 population) to the recent epidemic period in 1995-1996 (2.2 cases per 100 000).
The age-specific incidence rate of serogroup B disease among those 15 through 19 years old increased 13-fold between the preepidemic period (0.5 case per 100000) and 1995-1996 (6.4 cases per 100000).
However, the proportion of cases with meningococcemia and the case-fatality rate did not change.
Of 99 Neisseria meningitidis isolates obtained from 1993-1995,88 (89%) belonged to the ET-5 complex.
Of these, 69 (78%) were a single clone, designated 301. (...)
Mots-clés Pascal : Méningococcie, Bactériose, Infection, Neisseria meningitidis, Neisseriaceae, Micrococcales, Bactérie, Sérogroupe, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Souche pathogène, Evolution, Exploration, Homme
Mots-clés Pascal anglais : Meningococcal disease, Bacteriosis, Infection, Neisseria meningitidis, Neisseriaceae, Micrococcales, Bacteria, Serogroup, Epidemiology, United States, North America, America, Pathogen strain, Evolution, Exploration, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0258955
Code Inist : 002B05B02I. Création : 16/11/1999.