The association between pre-and postnatal tobacco smoke exposure and allergic sensitization during early childhood.
Passive Smoking & Children : Clinical & Experimental Forums. International Academic Symposium. Essen, DEU, 1998/08/25.
Aim of our study was to investigate the effect of pre-and postnatal passive tobacco smoke exposure on the incidence of allergic sensitization.
Patients and methods Specific sensitization to food, outdoor and indoor allergens was determined in 342 children at the age of 1,2 and 3 years.
Parents were asked about their smoking habit at the birth of their children, at 18 months and 3 years of age.
Results Multivariate regression analysis indicated, that during the first 3 years of life, pre-and postnatally exposed children had a significantly higher risk for sensitization to food allergens compared to children never exposed to tobacco smoke (OR 2.2,95% CI 1.1 - 4.2 ; P=0.02).
With respect to inhalant allergens no significant influence of tobacco smoke exposure on specific sensitization could be demonstrated.
Conclusion During early childhood both pre-and postnatal tobacco smoke exposure has an adjuvant effect on allergic sensitization to food allergens.
Mots-clés Pascal : Tabagisme passif, Toxicité, Gestation, Immunopathologie, Allergène, Epidémiologie, Tératogène, Descendance, Postnatal, Enfant, Homme, Allergie, Facteur risque, Tabagisme
Mots-clés Pascal anglais : Passive smoking, Toxicity, Pregnancy, Immunopathology, Allergen, Epidemiology, Teratogen, Progeny, Postnatal, Child, Human, Allergy, Risk factor, Tobacco smoking
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0258743
Code Inist : 002B03E. Création : 16/11/1999.