From in utero and childhood exposure to parental smoking to childhood cancer : a possible link and the need for action.
Passive Smoking & Children : Clinical & Experimental Forums. International Academic Symposium. Essen, DEU, 1998/08/25.
The objective ofthe present work is to critically summarize published studies and reassess the state of knowledge on a highly controversial topic : the potential association between prenatal exposure to passive smoking as well as maternal active smoking and postnatal exposure to environmental tobacco smoke (ETS) and enhanced incidence of childhood cancer.
Elements to be considered include the substantial proportion of pregnant women who remain smokers, the widespread nature of exposure to ETS during pregnancy as well as during childhood, the known toxicology of tobacco smoke, and in particular sidestream smoke, characterized by a rich carcinogen content, the specific metabolism of foetuses and new-borns and finally the amount of epidemiologic data already available.
We conducted a thorough review of the literature to identify studies either exclusively dealing with the effects of passive smoking on the occurrence of childhood cancers or more generally etiologic studies of cancer, be it overall or site-specific.
We identified close to 50 publications presenting pertinent results from epidemiological investigations and about 50 more on mechanisms and metabolism, smoking in pregnancy and exposure to ETS as well as selected reviews and commentaries.
Collaborative epidemiological studies were conducted in the United Kingdom (UK), USA, Sweden, Netherlands and internationally (France, Italy). (...)
Mots-clés Pascal : Article synthèse, Tabagisme passif, Milieu familial, Tumeur maligne, Enfant, Homme, Corrélation, Epidémiologie, Etude multicentrique, Facteur risque, Politique sanitaire, Prénatal, Postnatal, Gestation, Toxicité, Tabagisme
Mots-clés Pascal anglais : Review, Passive smoking, Family environment, Malignant tumor, Child, Human, Correlation, Epidemiology, Multicenter study, Risk factor, Health policy, Prenatal, Postnatal, Pregnancy, Toxicity, Tobacco smoking
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0258137
Code Inist : 002B03E. Création : 16/11/1999.